The respiratory depressant results of opioids involve carbon dioxide retention and secondary elevation of cerebrospinal fluid tension, and should be markedly exaggerated inside the presence of head injury, other intracranial lesions or perhaps a pre-existing boost in intracranial stress.Talk to your medical professional or pharmacist if you need to

In cases like this, abrupt discontinuation of your opioid may cause a withdrawal syndrome. If the discontinuation of opioids is therapeutically indicated, gradual tapering of your drug around a 2-week interval will protect against withdrawal indications. The severity in the withdrawal syndrome is dependent totally on the each day dosage from the op